Stereoselective synthesis of a protected form of (6R,7E,9S,10R,12Z)-6,9,10- trihydroxy-7,12-hexadecadienoic acid

Yusuke Kurashina, Shigefumi Kuwahara

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    The protected stereoisomer of a trihydroxy unsaturated fatty acid, which could be employed as a potential nigricanoside α-chain building block, was synthesized by using Evans asymmetric alkylation, Sharpless kinetic resolution, and diastereoselective reduction as the key steps.

    Original languageEnglish
    Pages (from-to)605-607
    Number of pages3
    JournalBioscience, Biotechnology and Biochemistry
    Volume76
    Issue number3
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Antimitotic
    • Cytotoxic
    • Fatty acid
    • Glycolipid
    • Nigricanoside

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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