Stereoselective synthesis of a protected form of (6R,7E,9S,10R,12Z)-6,9,10- trihydroxy-7,12-hexadecadienoic acid

Yusuke Kurashina, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The protected stereoisomer of a trihydroxy unsaturated fatty acid, which could be employed as a potential nigricanoside α-chain building block, was synthesized by using Evans asymmetric alkylation, Sharpless kinetic resolution, and diastereoselective reduction as the key steps.

Original languageEnglish
Pages (from-to)605-607
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number3
DOIs
Publication statusPublished - 2012 Apr 2

Keywords

  • Antimitotic
  • Cytotoxic
  • Fatty acid
  • Glycolipid
  • Nigricanoside

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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