Stereoselective synthesis of β-amino acid derivatives by asymmetric mannich reaction in flow

Masahito Yoshida, Koji Umeda, Takayuki Doi

Research output: Contribution to journalArticle

Abstract

A continuous flow synthesis of β-amino acid derivatives has been demonstrated using an asymmetric Mannich reaction. An enolate of tert-butyl acetate was successfully prepared in 10s at room temperature in a flow reactor, and the desired β-amino acid derivatives were stereoselectively obtained within a short residence time (40 s) in moderate-to-good yields. Sequential Nalkylation of the Mannich product in the flow reactor was also achieved in the presence of DMPU that provided N-alkylated β-amino acid derivatives in good yields.

Original languageEnglish
Pages (from-to)1157-1163
Number of pages7
JournalBulletin of the Chemical Society of Japan
Volume90
Issue number10
DOIs
Publication statusPublished - 2017 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)

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