Stereoselective construction of cis-decalin framework via radical domino cyclization

Eriko Suzuki, Minoru Ueda, Shigeru Ohba, Takeshi Sugai, Mitsuru Shoji

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Steroids with A/B cis-decalin moiety and various bioactivities have attracted many synthetic chemists as target molecules and development of efficient methodology providing cis-decalins has been desired. A stereoselective domino cyclization via Mn(OAc)3 and Cu(OTf)2-mediated radical reaction was found to be effective to construct cis-decalin framework.

Original languageEnglish
Pages (from-to)1589-1592
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number12
DOIs
Publication statusPublished - 2013 Mar 20

Keywords

  • Domino reaction
  • Radical cyclization
  • Stereoselective synthesis
  • Steriod
  • cis-Decalin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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