Abstract
In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea-sulfonamide organocatalyst afforded conjugate adducts in moderate to high yields (up to 81%) under mild reaction conditions. Excellent diastereoselectivity (up to 98:2 dr) and enantioselectivity (up to 88% ee) were achieved.
Original language | English |
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Pages (from-to) | 1215-1224 |
Number of pages | 10 |
Journal | Chirality |
Volume | 30 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2018 Nov |
Externally published | Yes |
Keywords
- alkylidene malonate
- asymmetric conjugate addition
- organocatalysis
- organocatalyst
- thiourea-sulfonamideIntroduction
ASJC Scopus subject areas
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry