Stereoselective approach to the racemic oxatetracyclic core of platensimycin

Sakuya Horii; Munefumi Torihata; Tomohiro Nagasawa; Shigefumi Kuwahara

doi:10.1021/jo302813y

Stereoselective approach to the racemic oxatetracyclic core of platensimycin

Sakuya Horii, Munefumi Torihata, Tomohiro Nagasawa, Shigefumi Kuwahara

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A highly stereoselective synthesis of the racemic oxatetracyclic core of platensimycin has been accomplished from a known bicyclic epoxy lactone by an 11-step sequence that involves a Diels-Alder cyclcoaddition to construct its cis-decalenone structural motif with complete regio- and stereoselectivity and a ring-closing metathesis to establish its whole carbon framework.

Original language	English
Pages (from-to)	2798-2801
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	78
Issue number	6
DOIs	https://doi.org/10.1021/jo302813y
Publication status	Published - 2013 Mar 15

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo302813y

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abstract = "A highly stereoselective synthesis of the racemic oxatetracyclic core of platensimycin has been accomplished from a known bicyclic epoxy lactone by an 11-step sequence that involves a Diels-Alder cyclcoaddition to construct its cis-decalenone structural motif with complete regio- and stereoselectivity and a ring-closing metathesis to establish its whole carbon framework.",

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