Abstract
Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers. We report a highly stereoselective 6-exo radical cyclization/ring-closing olefin metathesis sequence to construct the syn/trans-fused polyether system. The new method was applied to the practical synthesis of ciguatoxin CTX3C.
Original language | English |
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Pages (from-to) | 357-364 |
Number of pages | 8 |
Journal | Journal of Natural Products |
Volume | 74 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2011 Mar 25 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry