Stereoselective α-alkylation of α,β-unsaturated esters utilizing conjugate addition of nitrogen nucleophiles (R2NLi)

Tadao Uyehara, Naoki Asao, Yoshinori Yamamoto

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    Treatment of α,β-unsaturated esters (1) with lithium amides [LiNPri2 and LiN(CH2Ph)SiMe3] followed by alkylation and elimination of the amino groups produced trisubstituted enoates (2) with high stereoselectivity.

    Original languageEnglish
    Pages (from-to)1410-1411
    Number of pages2
    JournalJournal of the Chemical Society, Chemical Communications
    Issue number18
    DOIs
    Publication statusPublished - 1987 Dec 1

    ASJC Scopus subject areas

    • Molecular Medicine

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