Stereocontrolled total synthesis of (+)-vincristine

Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

An efficient total synthesis of (+)-vincristine has been accomplished through a stereoselective coupling of demethylvindoline and the eleven-membered carbomethoxyverbanamine presursor. Demethylvindoline was prepared by oxidation of 17-hydroxy-11-methoxytabersonine, followed by regioselective acetylation with mixed anhydride method. Although an initial attempt of coupling by using demethylvindoline formamide was not successful and resulted in recovery of the starting compounds, the reaction using demethylvindoline took place smoothly to furnish the desired bisindole product with the correct stereochemistry at C18′. After formation of the piperidine ring by sequential removal of the protective groups and intramolecular nucleophilic cyclization, the total synthesis of vincristine was completed by formylation of N1.

Original languageEnglish
Pages (from-to)11966-11970
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number33
DOIs
Publication statusPublished - 2004 Aug 17
Externally publishedYes

ASJC Scopus subject areas

  • General

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