Stereocontrolled synthesis of (+)-lycoperdic acid based on a palladium catalyzed reaction using a serine-derived organozinc reagent

Hidekazu Masaki, Tomoko Mizozoe, Tomoyuki Esumi, Yoshiharu Iwabuchi, Susumi Hatakeyama

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

An efficient stereocontrolled synthesis of (+)-lycoperdic acid has been achieved based on palladium catalyzed cross-coupling reaction of (Z)-1-(tert- butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene with the organozinc reagent, prepared from N-Boc-β-iodoalanine methyl ester. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)4801-4804
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number24
DOIs
Publication statusPublished - 2000 Jun 10
Externally publishedYes

Keywords

  • Amino acids
  • Coupling reactions
  • Organozinc compounds
  • Palladium catalyzed reactions

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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