Stereochemistry of enacyloxins 2. Structure elucidation of decarbamoyl enacyloxin IIa and IVa, new members of enacyloxin antibiotics from Frateuria sp. W-315

Toshihiko Watanabe, Hiromasa Kiyota, Ryo Takeuchi, Keijiro Enari, Takayuki Oritani

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Two new members of enacyloxins (ENXs) were isolated from the culture extract of Frateuria sp. W-315. Spectrometric analyses revealed their structures as decarbamoyl enacyloxin IVa and IIa, the latter preferentially existed in the hemiacetal form. Formation of these compounds were catalyzed by enzymes produced by the fungus. From the coupling constant values of the hemiacetal part of dec ENX IIa, the (17′R*, 18′S*, 19′R*) relative configuration of ENXs was also elucidated.

    Original languageEnglish
    Pages (from-to)313-316
    Number of pages4
    JournalHeterocyclic Communications
    Volume7
    Issue number4
    DOIs
    Publication statusPublished - 2001 Jan 1

    ASJC Scopus subject areas

    • Organic Chemistry

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