Stereo-controlled synthesis of analogs of peumusolide A, NES non-antagonistic inhibitor for nuclear export of MEK

Satoru Tamura, Masayuki Tonokawa, Nobutoshi Murakami

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Stereo-controlled construction of the core structure of peumusolide A (1), α-alkylidene-β-hydroxy-γ-methylenebutyrolactone, was developed by a combination of regio- and stereo-selective hydroiodination of 2-yn-1-ol and asymmetric reduction of 1-yn-4-en-3-one as the key reactions. By using this protocol, all the four stereoisomers of the analog of 1 were synthesized from the common starting material.

Original languageEnglish
Pages (from-to)3134-3137
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number23
DOIs
Publication statusPublished - 2010 Jun 9

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Stereo-controlled synthesis of analogs of peumusolide A, NES non-antagonistic inhibitor for nuclear export of MEK'. Together they form a unique fingerprint.

Cite this