Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: Synthesis of the A and C ring synthons of paclitaxel

Kazuoki Nakai, Miyuki Kamoshita, Takayuki Doi, Haruo Yamada, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.

Original languageEnglish
Pages (from-to)7855-7857
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number44
DOIs
Publication statusPublished - 2001 Oct 29
Externally publishedYes

Keywords

  • Cyclisation
  • Epoxides
  • Stereocontrol
  • Taxoids
  • Titanium and compounds

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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