Stepwise DNA condensation by a histone-mimic peptide-coated M 12L24 spherical complex

Takashi Kikuchi, Sota Sato, Daishi Fujita, Makoto Fujita

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    A nanosized M12L24 coordination sphere mimicking a histone-octamer, in size and charge density, was studied as an artificial DNA compaction core. It triggered a stepwise condensation process in a similar manner to that of the natural system. "Beads-on-a-string" and "multistrand aggregation" intermediates were clearly observed by atomic force microscopy (AFM) and dynamic light scattering (DLS) studies during the condensation process.

    Original languageEnglish
    Pages (from-to)3257-3260
    Number of pages4
    JournalChemical Science
    Volume5
    Issue number8
    DOIs
    Publication statusPublished - 2014 Aug

    ASJC Scopus subject areas

    • Chemistry(all)

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