Stepping beyond the newtonian paradigm in biology towards an integrable model of life: Accelerating discovery in the biological foundations of science

Plamen L. Simeonov, Edwin H. Brezina, Ron Cottam, Andrée C. Ehresmann, Arran Gare, Ted Goranson, Jaime Gomez-Ramirez, Brian D. Josephson, Bruno Marchal, Koichiro Matsuno, Robert S. Root-Bernstein, Otto E. Rössler, Stanley N. Salthe, Marcin J. Schroeder, Bill Seaman, Pridi Siregar, Leslie S. Smith

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Citations (Scopus)


The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort.

Original languageEnglish
Title of host publicationIntegral Biomathics
Subtitle of host publicationTracing the Road to Reality
PublisherSpringer Berlin Heidelberg
Number of pages99
ISBN (Electronic)9783642281112
ISBN (Print)9783642281105
Publication statusPublished - 2012 Jan 1
Externally publishedYes


  • Autopoiesis
  • Biocomputing
  • Biological mathematics
  • Biological time
  • Category theory
  • Change
  • Class identity
  • Cognition
  • Communication
  • Complementarity
  • Complexity
  • Consciousness
  • Determinism
  • Development
  • Developmental biology
  • Distribution
  • Emergence
  • Endophysics
  • First-person perspective
  • Genetic transcoding
  • Hierarchies
  • Holism
  • Individual identity
  • Information
  • Information integration
  • Integral biomathics
  • Internalism
  • Life
  • Logic
  • Mechanicism
  • Memory
  • Mind-body problem
  • Natural computing
  • Neural systems
  • Neuroscience
  • Non-deterministic chaos
  • Non-locality
  • Observer-participation
  • Positivism
  • Quantum effects in biology
  • Reductionism
  • Scale and hyperscale
  • Scientific revolution
  • Self-organization
  • Semiotics
  • Theoretical biology
  • Theoretical physics
  • Vagueness
  • Virtualization

ASJC Scopus subject areas

  • Computer Science(all)


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