The cardiovascular stent is one of the medical devices which has been commonly used for curing many vascular diseases. Nowadays, research on many aspects of stent development has been conducted to improve the device's efficacy. Mechanical and flow dynamics analysis on stent performance are useful to understand the impact of the device deployment. Many assumptions have been applied for constructing the stent simulation model including the blood vessel wall condition and its inlet flow conditions. Recently, common assumptions of the stent simulation model are mainly worked under the assumption of rigid wall condition and steady or pulsatile inlet flow. These different assumptions may lead to different simulation results. These differences may also affect the further analysis such as optimization process. This research tries to investigate the pulsatile effect on the stent optimization results based on computational simulation with wall deformation. Comparison with the previous optimization with a steady flow was conducted to find out about the differences between the two conditions. We found that the difference in optimization results from both inflow conditions is insignificant.