Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma

Takaaki Beppu, Kazunori Terasaki, Toshiaki Sasaki, Shunrou Fujiwara, Hideki Matsuura, Kuniaki Ogasawara, Koichiro Sera, Noriyuki Yamada, Noriyuki Uesugi, Tamotsu Sugai, Kohsuke Kudo, Makoto Sasaki, Shigeru Ehara, Ren Iwata, Yoshihiro Takai

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Purpose: The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[ 18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole ( 18F-FRP170). Procedures: Twelve patients with glioblastoma underwent 18F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of 18F-FRP170. In these areas, intratumoral oxygen pressure (tpO 2) was measured using microelectrodes during tumor resection. Results: Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area. Conclusion: The present findings suggest that high accumulation on 18F-FRP170 PET represents viable hypoxic tissues in glioblastoma.

    Original languageEnglish
    Pages (from-to)127-135
    Number of pages9
    JournalMolecular Imaging and Biology
    Volume16
    Issue number1
    DOIs
    Publication statusPublished - 2014 Feb

    Keywords

    • F-FRP170
    • Glioblastoma
    • HIF1-α
    • Hypoxia
    • Oxygen pressure
    • PET

    ASJC Scopus subject areas

    • Oncology
    • Radiology Nuclear Medicine and imaging
    • Cancer Research

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