TY - JOUR
T1 - Standardisation of the Japanese diet for use in animal experiments
AU - Sugawara, Saeko
AU - Mizowaki, Yui
AU - Iwagaki, Yui
AU - Sakamoto, Yu
AU - Yamamoto, Kazushi
AU - Tsuduki, Tsuyoshi
N1 - Funding Information:
This study was supported by grants from Integration Research for Agriculture and Interdisciplinary Fields and Integration Development Research for Agriculture and Interdisciplinary Fields, Ministry of Agriculture, Forestry and Fisheries of Japan and The Canon Foundation.
Publisher Copyright:
Copyright © The Authors 2017.
PY - 2017/11/28
Y1 - 2017/11/28
N2 - The aim of this study was to develop a purified diet that mimics the characteristics of the Japanese diet using readily available materials with a simpler composition and a focus on quality, with the goal of facilitating performance of studies on the Japanese diet worldwide. The utility of the new diet was examined as a mimic of the standard Japanese diet for use in animal experiments. We examined whether a key characteristic of the Japanese diet of being less likely to cause obesity could be reproduced. The mimic diet had a balance of protein, fat and carbohydrate based on the 1975 Japanese diet, which is the least likely to cause obesity, and materials chosen with reference to the National Health and Nutrition Survey (NHNS). To examine similarities of the mimic diet with the model 1975 Japanese diet, we created a menu of the 1975 diet based on the NHNS and prepared the freeze-dried and powdered diet. The mimic diet, the 1975 Japanese diet, a control AIN-93G diet and a Western diet were fed to mice for 4 weeks. As a result, the mimic diet and the 1975 diet resulted in less accumulation of visceral fat and liver fat. Mice given these two diets showed similar effects. This indicates that the mimic diet used in this study has characteristics of the 1975 Japanese diet and could be used as a standard Japanese diet in animal experiments.
AB - The aim of this study was to develop a purified diet that mimics the characteristics of the Japanese diet using readily available materials with a simpler composition and a focus on quality, with the goal of facilitating performance of studies on the Japanese diet worldwide. The utility of the new diet was examined as a mimic of the standard Japanese diet for use in animal experiments. We examined whether a key characteristic of the Japanese diet of being less likely to cause obesity could be reproduced. The mimic diet had a balance of protein, fat and carbohydrate based on the 1975 Japanese diet, which is the least likely to cause obesity, and materials chosen with reference to the National Health and Nutrition Survey (NHNS). To examine similarities of the mimic diet with the model 1975 Japanese diet, we created a menu of the 1975 diet based on the NHNS and prepared the freeze-dried and powdered diet. The mimic diet, the 1975 Japanese diet, a control AIN-93G diet and a Western diet were fed to mice for 4 weeks. As a result, the mimic diet and the 1975 diet resulted in less accumulation of visceral fat and liver fat. Mice given these two diets showed similar effects. This indicates that the mimic diet used in this study has characteristics of the 1975 Japanese diet and could be used as a standard Japanese diet in animal experiments.
KW - 1975 Japanese diet
KW - AIN-93
KW - Key words Japanese diet
KW - Mice
KW - Western diet
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U2 - 10.1017/S0007114517002793
DO - 10.1017/S0007114517002793
M3 - Review article
C2 - 29143690
AN - SCOPUS:85034572471
VL - 118
SP - 867
EP - 876
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 10
ER -