STAM2, a new member of the STAM family, binding to the Janus kinases

Kazuhiro Endo, Toshikazu Takeshita, Hirotake Kasai, Yoshiteru Sasaki, Nobuyuki Tanaka, Hironobu Asao, Kazu Kikuchi, Mitsuhiro Yamada, Min Chen, John J. O'Shea, Kazuo Sugamura

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Co-expression of the SH3 deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL-2 and GM-CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM-SCF and IL-2, respectively. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalFEBS Letters
Volume477
Issue number1-2
DOIs
Publication statusPublished - 2000 Jul 14

Keywords

  • GM-CSF
  • IL-2
  • Signal transduction
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Endo, K., Takeshita, T., Kasai, H., Sasaki, Y., Tanaka, N., Asao, H., Kikuchi, K., Yamada, M., Chen, M., O'Shea, J. J., & Sugamura, K. (2000). STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Letters, 477(1-2), 55-61. https://doi.org/10.1016/S0014-5793(00)01760-9