Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer

Yuichiro Nakamura, Yasuyoshi Miyata, Tomohiro Matsuo, Yohei Shida, Tomoaki Hakariya, Kojiro Ohba, Takenobu Taima, Akihiro Ito, Tetsuji Suda, Sen itiroh Hakomori, Seiichi Saito, Hideki Sakai

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression.

Original languageEnglish
Pages (from-to)409-418
Number of pages10
JournalGlycoconjugate Journal
Volume36
Issue number5
DOIs
Publication statusPublished - 2019 Oct 1
Externally publishedYes

Keywords

  • Apoptosis · prostate cancer
  • Biochemical recurrence
  • SSEA-4
  • Tumor-infiltrating immune cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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