Stabilization of micropatterned polymer films as artificial extracellular matrices for tissue engineering

Ryusuke Ookura, Jin Nishida, Takehiro Nishikawa, Masatsugu Shimomura

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Honeycomb-patterned polymer films are formed upon self-organization of water microspheres stabilized by amphiphilic polymers. The honeycomb films can work as cell culture substrates. The films composed of heparin-cationic lipid complex, however, gradually lost the honeycomb structure when immersed in culture medium. Crosslinking of the films was carried to stabilize the honeycomb pattern. A bisazido derivative was used as a crosslinker connecting the constituent polymer of the honeycomb films. Morphological study of the immersed films revealed that the crosslinked films maintained the honeycomb structure in the phosphate buffer solution.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalMolecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals
Volume337
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Amphiphilic polymers
  • Cell adhesion
  • Honeycomb films
  • Photo-crosslinking

ASJC Scopus subject areas

  • Condensed Matter Physics

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