Stabilization of micropatterned polymer films as artificial extracellular matrices for tissue engineering

Ryusuke Ookura, Jin Nishida, Takehiro Nishikawa, Masatsugu Shimomura

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Honeycomb-patterned polymer films are formed upon self-organization of water microspheres stabilized by amphiphilic polymers. The honeycomb films can work as cell culture substrates. The films composed of heparin-cationic lipid complex, however, gradually lost the honeycomb structure when immersed in culture medium. Crosslinking of the films was carried to stabilize the honeycomb pattern. A bisazido derivative was used as a crosslinker connecting the constituent polymer of the honeycomb films. Morphological study of the immersed films revealed that the crosslinked films maintained the honeycomb structure in the phosphate buffer solution.

    Original languageEnglish
    Pages (from-to)461-464
    Number of pages4
    JournalMolecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals
    Volume337
    DOIs
    Publication statusPublished - 1999 Jan 1

    Keywords

    • Amphiphilic polymers
    • Cell adhesion
    • Honeycomb films
    • Photo-crosslinking

    ASJC Scopus subject areas

    • Condensed Matter Physics

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