Stabilization of liquid interface and control of two-phase confluence and separation in glass microchips by utilizing octadecylsilane modification of microchannels

Akihide Hibara, Masaki Nonaka, Hideaki Hisamoto, Kenji Uchiyama, Yoshikuni Kikutani, Manabu Tokeshi, Takehiko Kitamori

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)

Abstract

We demonstrated a liquid/liquid and a gas/liquid two-phase crossing flow in glass microchips. A 250-μm-wide microchannel for aqueous-phase flow was fabricated on a top glass plate. Then, as a way to utilize the surface energy difference for stable phase confluence and separation, a 250-μm-wide microchannel for organic-phase (or gas-phase) flow was fabricated on a bottom glass plate and the wall was chemically modified by octadecylsilane (ODS) group. The top and bottom plates were sealed only by pressure. A microchannel pattern was designed so that the two phases made contact at the crossing point of the straight microchannels. The crossing point was observed with an optical microscope. Results showed that the ODS modification of the microchannel wall clearly improved stability of the interface between the two fluids. Pressure difference between fluids was measured and the interface of water and nitrobenzene was stable for the pressure difference from +300 Pa to -200 Pa. The pressure drop in a countercurrent flow configuration was also estimated, and the pressure difference required to realize the countercurrent flow was less than the allowable pressure range. Finally, we discussed the advantages of utilizing this approach.

Original languageEnglish
Pages (from-to)1724-1728
Number of pages5
JournalAnalytical Chemistry
Volume74
Issue number7
DOIs
Publication statusPublished - 2002 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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