Stability of L-[S-methyl-11C]methionine solutions

A. Bogni; E. Bombardieri; R. Iwata; L. Cadini; C. Pascali

doi:10.1023/A:1023964712999

Stability of L-[S-methyl-¹¹C]methionine solutions

A. Bogni, E. Bombardieri, R. Iwata, L. Cadini, C. Pascali

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

For clinical PET studies L-[S-methyl-¹¹C]methionine (¹¹C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/μmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.

Original language	English
Pages (from-to)	199-203
Number of pages	5
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	256
Issue number	2
DOIs	https://doi.org/10.1023/A:1023964712999
Publication status	Published - 2003 May 1

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1023964712999

Cite this

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title = "Stability of L-[S-methyl-11C]methionine solutions",

abstract = "For clinical PET studies L-[S-methyl-11C]methionine (11C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/μmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.",

author = "A. Bogni and E. Bombardieri and R. Iwata and L. Cadini and C. Pascali",

note = "Funding Information: The authors wish to acknowledge the financial support from the Associazione Italiana per la Ricerca sul Cancro and from the “Progetto Finalizzato” of the Italian Ministry of Health and Dr. B. BAUER and Dr. R. WAGNER for their helpful discussion.",

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T1 - Stability of L-[S-methyl-11C]methionine solutions

AU - Bogni, A.

AU - Bombardieri, E.

AU - Iwata, R.

AU - Cadini, L.

AU - Pascali, C.

N1 - Funding Information: The authors wish to acknowledge the financial support from the Associazione Italiana per la Ricerca sul Cancro and from the “Progetto Finalizzato” of the Italian Ministry of Health and Dr. B. BAUER and Dr. R. WAGNER for their helpful discussion.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - For clinical PET studies L-[S-methyl-11C]methionine (11C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/μmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.

AB - For clinical PET studies L-[S-methyl-11C]methionine (11C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/μmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.

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