Stability of L-[S-methyl-11C]methionine solutions

A. Bogni, E. Bombardieri, R. Iwata, L. Cadini, C. Pascali

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    For clinical PET studies L-[S-methyl-11C]methionine (11C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/μmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.

    Original languageEnglish
    Pages (from-to)199-203
    Number of pages5
    JournalJournal of Radioanalytical and Nuclear Chemistry
    Volume256
    Issue number2
    DOIs
    Publication statusPublished - 2003 May 1

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Nuclear Energy and Engineering
    • Radiology Nuclear Medicine and imaging
    • Pollution
    • Spectroscopy
    • Public Health, Environmental and Occupational Health
    • Health, Toxicology and Mutagenesis

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