Stabilities of 67Ga- and 111in-labeled transferrin In Vitro

Yosuke Ohtake; Akiko Maruko; Yoshikazu Kuwahara; Manabu Fukumoto; Yasuhito Ohkubo

doi:10.2174/092986609787316298

Stabilities of ⁶⁷Ga- and ¹¹¹in-labeled transferrin In Vitro

Yosuke Ohtake, Akiko Maruko, Yoshikazu Kuwahara, Manabu Fukumoto, Yasuhito Ohkubo

Division of Cancer Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. ⁶⁷Ga and ¹¹¹In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that ¹¹¹ In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. ¹¹¹ In-DTPA-Tf was also the most stable radiolabeled transferrin in the blood.

Original language	English
Pages (from-to)	138-142
Number of pages	5
Journal	Protein and Peptide Letters
Volume	16
Issue number	2
DOIs	https://doi.org/10.2174/092986609787316298
Publication status	Published - 2009 Feb 1

Keywords

DTPA
Ga
In
Radiolabeling
Transferrin

ASJC Scopus subject areas

Structural Biology
Biochemistry

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abstract = "We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111 In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111 In-DTPA-Tf was also the most stable radiolabeled transferrin in the blood.",

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AU - Ohtake, Yosuke

AU - Maruko, Akiko

AU - Kuwahara, Yoshikazu

AU - Fukumoto, Manabu

AU - Ohkubo, Yasuhito

PY - 2009/2/1

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N2 - We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111 In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111 In-DTPA-Tf was also the most stable radiolabeled transferrin in the blood.

AB - We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111 In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111 In-DTPA-Tf was also the most stable radiolabeled transferrin in the blood.

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KW - In

KW - Radiolabeling

KW - Transferrin

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