Abstract
The tBu-P4 base was found to be an excellent catalyst for the activation of organozinc reagents. The base was used to promote the SN2′ reaction of α,β-unsaturated esters bearing a γ-chloride in the reactions with various organozinc reagents in the presence of LiCl. The reactions proceeded in high yield with excellent chemo-and regioselectivity. The role of LiCl appears to be the activation of the y-chloride of the α,β-unsaturated esters, which was confirmed by NMR spectroscopic study.
Original language | English |
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Pages (from-to) | 9805-9809 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 15 |
Issue number | 38 |
DOIs | |
Publication status | Published - 2009 Sep 28 |
Keywords
- Lithium
- Nucleophilic substitution
- Phosphazene bases
- Zinc
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Organic Chemistry