SPR-based DNA detection with metal nanoparticles

Kaoru Tamada; Fumio Nakamura; Masateru Ito; Xinheng Li; Akira Baba

doi:10.1007/s11468-007-9035-x

SPR-based DNA detection with metal nanoparticles

Kaoru Tamada, Fumio Nakamura, Masateru Ito, Xinheng Li, Akira Baba

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Plasmonics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1007/s11468-007-9035-x
Publication status	Published - 2007 Dec
Externally published	Yes

Keywords

DNA array
DNA hybridization
Local plasmon
Maxwell-Garnett theory
Metal nanoparticles
Surface plasmon resonance (SPR)

ASJC Scopus subject areas

Biotechnology
Biophysics
Biochemistry

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10.1007/s11468-007-9035-x

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title = "SPR-based DNA detection with metal nanoparticles",

abstract = "In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.",

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author = "Kaoru Tamada and Fumio Nakamura and Masateru Ito and Xinheng Li and Akira Baba",

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language = "English",

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T1 - SPR-based DNA detection with metal nanoparticles

AU - Tamada, Kaoru

AU - Nakamura, Fumio

AU - Ito, Masateru

AU - Li, Xinheng

AU - Baba, Akira

PY - 2007/12

Y1 - 2007/12

N2 - In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.

AB - In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.

KW - DNA array

KW - DNA hybridization

KW - Local plasmon

KW - Maxwell-Garnett theory

KW - Metal nanoparticles

KW - Surface plasmon resonance (SPR)

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SPR-based DNA detection with metal nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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