Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques

Chiho Ishida; A. Kakishima; S. Okino; Y. Furukawa; M. Kano; Y. Oda; I. Nakanishi; T. Makifuchi; T. Kitamoto; M. Yamada

doi:10.1212/01.WNL.0000044403.41041.A4

Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques

Chiho Ishida, A. Kakishima, S. Okino, Y. Furukawa, M. Kano, Y. Oda, I. Nakanishi, T. Makifuchi, T. Kitamoto, M. Yamada

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The authors report a 75-year-old woman with atypical sporadic Creutzfeldt-Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft-associated CJD or shared host genetic factors that are unrelated to the PrP genotype.

Original language	English
Pages (from-to)	514-517
Number of pages	4
Journal	Neurology
Volume	60
Issue number	3
DOIs	https://doi.org/10.1212/01.WNL.0000044403.41041.A4
Publication status	Published - 2003 Feb 11

ASJC Scopus subject areas

Clinical Neurology

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T1 - Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques

AU - Ishida, Chiho

AU - Kakishima, A.

AU - Okino, S.

AU - Furukawa, Y.

AU - Kano, M.

AU - Oda, Y.

AU - Nakanishi, I.

AU - Makifuchi, T.

AU - Kitamoto, T.

AU - Yamada, M.

PY - 2003/2/11

Y1 - 2003/2/11

N2 - The authors report a 75-year-old woman with atypical sporadic Creutzfeldt-Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft-associated CJD or shared host genetic factors that are unrelated to the PrP genotype.

AB - The authors report a 75-year-old woman with atypical sporadic Creutzfeldt-Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft-associated CJD or shared host genetic factors that are unrelated to the PrP genotype.

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Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques

Abstract

ASJC Scopus subject areas

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