Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques

Chiho Ishida, A. Kakishima, S. Okino, Y. Furukawa, M. Kano, Y. Oda, I. Nakanishi, T. Makifuchi, T. Kitamoto, M. Yamada

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The authors report a 75-year-old woman with atypical sporadic Creutzfeldt-Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft-associated CJD or shared host genetic factors that are unrelated to the PrP genotype.

Original languageEnglish
Pages (from-to)514-517
Number of pages4
JournalNeurology
Volume60
Issue number3
DOIs
Publication statusPublished - 2003 Feb 11

ASJC Scopus subject areas

  • Clinical Neurology

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