Spontaneous remission of minimal change nephrotic syndrome in an elderly man

Yuki Chiba, Tasuku Nagasawa, Saori Kin, Kei Takahashi, Mai Yoshida, Yuji Oe, Koji Okamoto, Hiroshi Sato, Mariko Miyazaki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Minimal change nephrotic syndrome (MCNS) cases achieving spontaneous remission without external factors are rarely reported. We report a case of MCNS that achieved spontaneous remission without external factors that triggered its onset. An 82-year-old male patient was admitted to the hospital for close examination of nephrotic syndrome. Renal biopsy was performed and MCNS was diagnosed. Owing to the patient's age and history of foot and microvascular arteriovenous thrombosis, we did not start immunosuppressive drugs, including steroids, and opted for conservative management. After conservative treatment, proteinuria gradually decreased, and the patient achieved complete remission. Given that the patient had a history of urinary protein and thrombosis, recurrence of MCNS was considered again this time. In addition, the involvement of external factors that trigger the onset of MCNS was not found. In conclusion, in elderly-onset MCNS, clinicians generally hesitate to initiate treatment with an immunosuppressive drug, containing steroids, because of its many complications. Thus, our data provide valuable insight into MCNS.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalCEN case reports
Issue number2
Publication statusPublished - 2021 May 1


  • Adult minimal change nephrotic syndrome
  • Lymphocytes
  • Renal pathology
  • Spontaneous remission

ASJC Scopus subject areas

  • Medicine(all)


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