Spontaneous regression of blastic plasmacytoid dendritic cell neoplasm following sepsis by Serratia marcescens: A case report and literature review

Akane Suzuki, Shori Abe, Kaori Koyama, Shinju Suzuki, Munenori Nagao, Masahiro Kobayashi, Jun Nomura, Tomomi Tsutsumi, Tomoki Takeda, Yumiko Oka, Yuko Shirota, Naruhiko Takasawa, Takao Kodera, Yoko Okitsu, Shinichiro Takahashi, Ryo Ichinohasama, Junichi Kameoka

Research output: Contribution to journalArticlepeer-review

Abstract

Spontaneous regression is rare in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). An 85-year-old man presented with pancytopenia and skin lesions, and the bone marrow exhibited 79.6% CD4+, CD56+, CD123+, and TCL-1+ abnormal cells, with a normal karyotype; he was thus diagnosed with BPDCN. While being followed without chemotherapy, he was admitted due to sepsis induced by Serratia marcescens, which was successfully treated with antibiotics. Notably, his blood cell counts improved, and the skin lesions disappeared. To our knowledge, this is the first reported case of spontaneous regression of BPDCN with a decrease in tumor cells in the bone marrow following sepsis.

Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalInternal Medicine
Volume60
Issue number6
DOIs
Publication statusPublished - 2021

Keywords

  • Blastic plasmacytoid dendritic cell neoplasm
  • Sepsis
  • Serratia marcescens
  • Spontaneous regression

ASJC Scopus subject areas

  • Internal Medicine

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