Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

T. Ono, Y. Miyamura, H. Ikehata, H. Yamanaka, A. Kurishita, K. Yamamoto, T. Suzuki, T. Nohmi, M. Hayashi, T. Sofuni

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10-5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10-5 at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalMutation Research DNAging
Volume338
Issue number1-6
DOIs
Publication statusPublished - 1995 Oct

Keywords

  • Ageing
  • Spleen
  • Spontaneous mutation
  • lacZ: Muta mouse

ASJC Scopus subject areas

  • Ageing
  • Molecular Biology
  • Genetics

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