TY - JOUR
T1 - Spontaneous Alignment of a Three-Dimensional Model of Cultured Endothelial Cells under Steady Flow Conditions Studied by Computational Fluid Mechanics as an Emergent System
AU - Yamamoto, Yasuhito
AU - Yamaguchi, Takami
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Spontaneous alignment of arterial endothelial cells was simulated using a three-dimensional computational fluid mechanical model of cultured endothelial cells. Endothelial cells were simulated using a 2D Gaussian distribution function, and placed on a flat plate with randomly assigned rotational movement. The Navier-Stokes equations of Newtonian fluid under steady flow conditions were solved using a finite volume method, and the absolute wall shear stress (WSS) at the summit of cells was calculated. Only the movement of cells which reduces the WSS was conserved under steady flow condition. The cell model eventually showed alignment after varying lengths of simulation time. This phenomenon was thought to simulate the flow-induced alignment of the endothelial cells in vivo.
AB - Spontaneous alignment of arterial endothelial cells was simulated using a three-dimensional computational fluid mechanical model of cultured endothelial cells. Endothelial cells were simulated using a 2D Gaussian distribution function, and placed on a flat plate with randomly assigned rotational movement. The Navier-Stokes equations of Newtonian fluid under steady flow conditions were solved using a finite volume method, and the absolute wall shear stress (WSS) at the summit of cells was calculated. Only the movement of cells which reduces the WSS was conserved under steady flow condition. The cell model eventually showed alignment after varying lengths of simulation time. This phenomenon was thought to simulate the flow-induced alignment of the endothelial cells in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0029589791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029589791&partnerID=8YFLogxK
U2 - 10.11239/jsmbe1963.33.352
DO - 10.11239/jsmbe1963.33.352
M3 - Article
AN - SCOPUS:0029589791
VL - 33
SP - 352
EP - 364
JO - Japanese Journal of Medical Electronics and Biological Engineering
JF - Japanese Journal of Medical Electronics and Biological Engineering
SN - 0021-3292
IS - 4
ER -