Splice variants in apoptotic pathway

K. Miura, W. Fujibuchi, M. Unno

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)

Abstract

Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term "apoptosis" was introduced by Kerr et al. in 1972; among the programmed cell death, a variety of therapeutic strategies especially targeting apoptotic pathways have been investigated. Alternative precursor messenger RNA splicing, by which the process the exons of pre-mRNA are spliced in different arrangements to produce structurally and functionally distinct mRNA and proteins, is another field in progress, and it has been recognized as one of the most important mechanisms that maintains genomic and functional diversity. A variety of apoptotic genes are regulated through alternative pre-mRNA splicing as well, some of which have important functions as pro-apoptotic and anti-apoptotic factors. In this article we summarized splice variants of some of the apoptotic genes including BCL2L1, BIRC5, CFLAR, and MADD, as well as the regulatory mechanisms of alternative splicing of these genes. If the information of the apoptosis and aberrant splicing in each of malignancies is integrated, it will become possible to target proper variants for apoptosis, and the trans-elements themselves can become specific targets of cancer therapy as well. This article is part of a Special Issue entitled "Apoptosis: Four Decades Later".

Original languageEnglish
Pages (from-to)212-217
Number of pages6
JournalExperimental Oncology
Volume34
Issue number3
Publication statusPublished - 2012 Sep
Externally publishedYes

Keywords

  • Alternative pre-mRNA splicing
  • Apoptosis
  • Malignancy
  • Splice variants
  • Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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