Spin-trapping study of DNA cleavage induced by enediyne C-1027 chromophore

Toyonobu Usuki, Masayuki Inoue, Kimio Akiyama, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We report the direct observation of radical intermediates in the course of the DNA cleavage induced by the chromoprotein antitumor agent C-1027 using spin-trapping methods. An intriguing difference of behaviors was found between MNP (2-methyl-2-nitrosopropane) and DMPO (5,5-dimethyl-1-pyrroline N-oxide).

Original languageEnglish
Pages (from-to)1148-1149
Number of pages2
JournalChemistry Letters
Issue number11
Publication statusPublished - 2002 Nov 5

ASJC Scopus subject areas

  • Chemistry(all)


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