Spin-trapping reactions of a novel gauchetype radical trapper G-CYPMPO

Toshitaka Oka, Shinichi Yamashita, Masamichi Midorikawa, Seiichi Saiki, Yusa Muroya, Masato Kamibayashi, Masayuki Yamashita, Kazunori Anzai, Yosuke Katsumura

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Chemical reactions of a novel gauchetype spin trap, G-CYPMPO (sc-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-5-methy-1-pyrroline N-oxide, O1-P1-C6-N1 torsion angle = 52.8°), with reactive oxygen species were examined by pulse radiolysis technique with 35 MeV electron beam and by electron spin resonance spectroscopy after 60Co γ-ray irradiation. The spin-trapping reaction rate constants of G-CYPMPO toward the hydroxyl radical and the hydrated electron were estimated to be (4.2 ± 0.1) × 10 9 and (11.8 ± 0.2) × 10 9 M -1s -1, respectively. Half-lives of the spin adducts, hydroxyl radical, and perhydroxyl radical adducted G-CYPMPO were estimated to be ∼35 and ∼90 min, respectively. A comparison of the results with earlier reports using different radical sources suggests that the purity of the solution and/or the radical generation technique may influence the stability of the spin adducts.

Original languageEnglish
Pages (from-to)9600-9604
Number of pages5
JournalAnalytical Chemistry
Volume83
Issue number24
DOIs
Publication statusPublished - 2011 Dec 15
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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