Spectroscopic analyses of DNA duplexes in the presence of mercury ions.

Hiroshi Yamaguchi, Shuji Oda, Chojiro Kojima, Akira Ono, Yoshinori Kondo, Yoshiyuki Tanaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The DNA duplex with tandem T x T mismatches in the presence of Hg(II) has been studied by NMR spectroscopy. For this study, we synthesized decamer duplex with two successive T x T mismatches (TT10). From two-dimensional (2D) 1H-1H NOESY spectrum of TT10 in complex with Hg(II), we were able to trace sequential NOE walks between base protons and anomeric protons (H1'), and assigned all of them. Based on these assignments and NOESY spectra, we could assigned all the non-exchangeable protons of TT10 in the presence of Hg(II).

Original languageEnglish
Pages (from-to)199-200
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Medicine(all)

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