Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy

R. Inagi, T. Miyata, D. Suzuki, M. Toyoda, T. Wada, Y. Ueda, Y. Izuhara, H. Sakai, M. Nangaku, K. Kurokawa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Mesangial cells play critical roles in maintaining a structure and function of the glomerulus. We previously cloned a novel mesangium-predominant gene, megsin, a new serine protease inhibitor. To clarify localization and roles of megsin protein, we raised polyclonal antibodies to megsin. By immunohistochemistry, megsin protein was specifically identified in the mesangial area. The amount of megsin protein was increased in glomeruli of patients with IgA nephropathy than in those of normal individuals and of patients with minimal change nephrotic syndrome or membranous nephropathy, suggesting a pathophysiological role of megsin as a functional modulator of mesangial functions in situ.

Original languageEnglish
Pages (from-to)1098-1106
Number of pages9
JournalBiochemical and biophysical research communications
Volume286
Issue number5
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Keywords

  • IgA nephropathy
  • Megsin
  • Mesangial cell
  • Recombinant protein
  • Serpin
  • Synthetic peptide

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy'. Together they form a unique fingerprint.

Cite this