Specific interaction between 5'-aminonucleosides and borates and influence of borates on nucleoside conformations.

T. Wada, N. Minamimoto, Y. Inaki, Y. Inoue

Research output: Contribution to journalArticle

Abstract

The unique conformation and orientational change of 5'-amino-5'-deoxyuridine in Kolthoff's buffer is discussed. From CD and NOE spectra, anomalous syn orientation of Urd-5'-NH2 might be caused by specific interaction between borates and Urd-5'-NH2, which promote the formation of hydrogen bonding between 2-carbonyl oxygen and hydrogen of 5'-amino group. This borates induced syn orientation of Urd-5'-NH2 could be applied to external stimulation control of target RNA/DNA hybridization.

Original languageEnglish
Pages (from-to)9-10
Number of pages2
JournalNucleic acids symposium series
Issue number37
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Medicine(all)

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