Specific inhibitors of puromycin-sensitive aminopeptidase with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton

Yotaro Matsumoto, Tomomi Noguchi-Yachide, Masaharu Nakamura, Yusuke Mita, Akiyoshi Numadate, Yuichi Hashimoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.

Original languageEnglish
Pages (from-to)1449-1463
Number of pages15
JournalHeterocycles
Volume86
Issue number2
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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