Specific inhibition of TH2-type cytokine production from human peripheral T cells by terfenadine in vitro

Y. Munakata, Y. Umezawa, S. Iwata, R. P. Dong, S. Yoshida, T. Ishii, C. Morimoto

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Background: Cytokine imbalance is thought to be one of the causes for allergic diseases. The effect of anti-allergic drugs on cytokine production from T cells should be examined in a convenient way. Objectives: To study the in vitro effect of terfenadine, a prototype non-sedating HI receptor antagonist, on cytokine production from activated T cells. Methods: T cells were cultured in the presence of terfenadine on anti-CD3 mAb and anti-CD26 mAb-coated wells, anti-CD3 mAb and anti-CD28 mAb-coated wells, and anti-CD3 mAb wells with PMA. T-cell proliferation, along with the concentrations of interleukin (IL) -2, interferon (IFN) -γ, IL-4, and IL-5 were measured. Results: Terfenadine inhibited T-cell proliferation and IL-4 and IL-5 production under each costimulatory condition tested, whereas it had no effect on IL-2 and IFN-γ production. Conclusions: These results indicate that terfenadine has a specific inhibitory effect on TH2-type cytokine production induced by several ways of costimulatory activation.

Original languageEnglish
Pages (from-to)1281-1286
Number of pages6
JournalClinical and Experimental Allergy
Issue number9
Publication statusPublished - 1999
Externally publishedYes


  • CD26
  • CD28
  • CD3
  • Costimulation
  • Interferon-gamma
  • Interleukin- 2
  • Interleukin-4
  • Interleukin-5
  • T cell
  • Terfenadine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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