Abstract
Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic 'traditional' GST-P positive loci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.
Original language | English |
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Pages (from-to) | 957-961 |
Number of pages | 5 |
Journal | International Journal of Oncology |
Volume | 13 |
Issue number | 5 |
Publication status | Published - 1998 Nov 1 |
Keywords
- Eker rat
- Hepatocellular adenoma
- N-ethyl-N-nitrosourea
- Tsc2 gene
ASJC Scopus subject areas
- Oncology
- Cancer Research