Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat

Tomokazu Fukuda, Hiroaki Mitani, Masahiro Tsutsumi, Yoichi Konishi, Okio Hino

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    8 Citations (Scopus)

    Abstract

    Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic 'traditional' GST-P positive loci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.

    Original languageEnglish
    Pages (from-to)957-961
    Number of pages5
    JournalInternational Journal of Oncology
    Volume13
    Issue number5
    Publication statusPublished - 1998 Nov 1

    Keywords

    • Eker rat
    • Hepatocellular adenoma
    • N-ethyl-N-nitrosourea
    • Tsc2 gene

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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