Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat

Tomokazu Fukuda; Hiroaki Mitani; Masahiro Tsutsumi; Yoichi Konishi; Okio Hino

Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat

Tomokazu Fukuda, Hiroaki Mitani, Masahiro Tsutsumi, Yoichi Konishi, Okio Hino

AGR - Biological Resource Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic 'traditional' GST-P positive loci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.

Original language	English
Pages (from-to)	957-961
Number of pages	5
Journal	International Journal of Oncology
Volume	13
Issue number	5
Publication status	Published - 1998 Nov 1

Keywords

Eker rat
Hepatocellular adenoma
N-ethyl-N-nitrosourea
Tsc2 gene

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat",

abstract = "Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic 'traditional' GST-P positive loci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.",

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T1 - Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat

AU - Fukuda, Tomokazu

AU - Mitani, Hiroaki

AU - Tsutsumi, Masahiro

AU - Konishi, Yoichi

AU - Hino, Okio

PY - 1998/11/1

Y1 - 1998/11/1

N2 - Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic 'traditional' GST-P positive loci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.

AB - Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic 'traditional' GST-P positive loci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.

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