Specific increase in serum autotaxin activity in patients with pancreatic cancer

Yousuke Nakai, Hitoshi Ikeda, Kazuhiro Nakamura, Yukio Kume, Mitsuhiro Fujishiro, Naoki Sasahira, Kenji Hirano, Hiroyuki Isayama, Minoru Tada, Takao Kawabe, Yutaka Komatsu, Masao Omata, Junken Aoki, Kazuhiko Koike, Yutaka Yatomi

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Objectives: To evaluate the potential clinical significance of serum autotaxin (ATX) level in patients with cancers of the digestive system. Design and methods: Serum ATX activity was measured as the lysophospholipase D activity in patients with cancer of the esophagus (n= 8), stomach (n= 18), colorectum (n= 21), biliary tract (n= 19), or pancreas (n= 103) and in patients with benign pancreatic diseases (n = 73). Results: Among patients with various cancers of digestive system, increased serum ATX activity was predominantly observed among pancreatic cancer patients. Serum ATX activity was not increased in patients with chronic pancreatitis or pancreatic cysts. In the diagnosis of pancreatic cancer, the area under the receiver operating curve for serum ATX activity was 0.541 (95% CI, 0.435-0.648) for men and 0.772 (95% CI, 0.659-0.885) for women. No significant correlation was observed between serum ATX activity and CEA, CA19-9 or Dupan2 levels. Conclusion: Serum ATX activity may be useful for identifying pancreatic cancer when used together with other serum markers of pancreatic cancer.

Original languageEnglish
Pages (from-to)576-581
Number of pages6
JournalClinical Biochemistry
Issue number8-9
Publication statusPublished - 2011 Jun


  • Autotaxin
  • Lysophosphatidic acid
  • Lysophospholipase D
  • Pancreatic cancer

ASJC Scopus subject areas

  • Clinical Biochemistry


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