Specific dopaminergic neurons for the formation of labile aversive memory

Yoshinori Aso, Igor Siwanowicz, Lasse Bräcker, Kei Ito, Toshihiro Kitamoto, Hiromu Tanimoto

Research output: Contribution to journalArticlepeer-review

184 Citations (Scopus)

Abstract

A paired presentation of an odor and electric shock induces aversive odor memory in Drosophila melanogaster [1, 2]. Electric shock reinforcement is mediated by dopaminergic neurons [3-5], and it converges with the odor signal in the mushroom body (MB) [2, 6-8]. Dopamine is synthesized in ∼280 neurons that form distinct cell clusters [9-11] and is involved in a variety of brain functions [9, 12-20]. Recently, one of the dopaminergic clusters (PPL1) that includes MB-projecting neurons was shown to signal reinforcement for aversive odor memory [21]. As each dopaminergic cluster contains multiple types of neurons with different projections and physiological characteristics [11, 20], functional understanding of the circuit for aversive memory requires cellular identification. Here, we show that MB-M3, a specific type of dopaminergic neurons in the PAM cluster, is preferentially required for the formation of labile memory. Strikingly, flies formed significant aversive odor memory without electric shock when MB-M3 was selectively stimulated together with odor presentation. In addition, we identified another type of dopaminergic neurons in the PPL1 cluster, MB-MP1, which can induce aversive odor memory. As MB-M3 and MB-MP1 target the distinct subdomains of the MB, these reinforcement circuits might induce different forms of aversive memory in spatially segregated synapses in the MB.

Original languageEnglish
Pages (from-to)1445-1451
Number of pages7
JournalCurrent Biology
Volume20
Issue number16
DOIs
Publication statusPublished - 2010 Aug 24
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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