Specific alteration of the form of selenium in fetal liver on maternal methylmercury treatment

Noriko Nishikido, Yasuko Satoh, Izumi Iwai, Mina Ishii, Akira Naganuma, Nobumasa Imura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We have recently reported that maternal administration of methylmercury caused a striking increase in the selenium concentration in fetal liver accompanied by a decrease in selenium-dependent glutathione peroxidase (GSH-Px) activity. These changes resulted in the lowered bioavailability of selenium as far as the GSH-Px activity was concerned. The present study demonstrated that maternal administration of methylmercury caused a specific alteration of the form of selenium in fetal liver. Sephadex G-200 gel filtration of liver cytosols revealed an additional major peak of selenium in the fetal livers of mice treated with methylmercury. This peak was not present in the liver, kidney, or placenta of mothers treated with methylmercury.

Original languageEnglish
Pages (from-to)497-499
Number of pages3
JournalToxicology and Applied Pharmacology
Volume92
Issue number3
DOIs
Publication statusPublished - 1988 Mar 15

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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