TY - JOUR
T1 - Specific alteration of the form of selenium in fetal liver on maternal methylmercury treatment
AU - Nishikido, Noriko
AU - Satoh, Yasuko
AU - Iwai, Izumi
AU - Ishii, Mina
AU - Naganuma, Akira
AU - Imura, Nobumasa
PY - 1988/3/15
Y1 - 1988/3/15
N2 - We have recently reported that maternal administration of methylmercury caused a striking increase in the selenium concentration in fetal liver accompanied by a decrease in selenium-dependent glutathione peroxidase (GSH-Px) activity. These changes resulted in the lowered bioavailability of selenium as far as the GSH-Px activity was concerned. The present study demonstrated that maternal administration of methylmercury caused a specific alteration of the form of selenium in fetal liver. Sephadex G-200 gel filtration of liver cytosols revealed an additional major peak of selenium in the fetal livers of mice treated with methylmercury. This peak was not present in the liver, kidney, or placenta of mothers treated with methylmercury.
AB - We have recently reported that maternal administration of methylmercury caused a striking increase in the selenium concentration in fetal liver accompanied by a decrease in selenium-dependent glutathione peroxidase (GSH-Px) activity. These changes resulted in the lowered bioavailability of selenium as far as the GSH-Px activity was concerned. The present study demonstrated that maternal administration of methylmercury caused a specific alteration of the form of selenium in fetal liver. Sephadex G-200 gel filtration of liver cytosols revealed an additional major peak of selenium in the fetal livers of mice treated with methylmercury. This peak was not present in the liver, kidney, or placenta of mothers treated with methylmercury.
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U2 - 10.1016/0041-008X(88)90189-5
DO - 10.1016/0041-008X(88)90189-5
M3 - Article
C2 - 3353994
AN - SCOPUS:0023848077
SN - 0041-008X
VL - 92
SP - 497
EP - 499
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 3
ER -