Spatio-temporal dynamics of a myelinated nerve fiber model in response to staircase-shape extracellular electrical stimulation

Ayako Ueno, Norihiro Katayama, Akihiro Karashima, Mitsuyuki Nakao

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that position- or diameter-selective recruitment of myelinated axons can be achieved by up-staircase-shape electrical nerve stimulation delivered from an extracellular electrode. However, so far, detail properties of the position- or diameter-selectivity of the stimulation have not been clarified. In this study, we investigated the spatio-temporal dynamics of myelinated axons in response to staircase-shape stimulation by numerical simulation of a compartmental model of rabbit myelinated axons. We found that the upstaircase-shape stimulation activates not only the targeted axons but also the ones close to the electrode by anodal break excitation this property would degrade the distance selectivity of the stimulation. By considering the mechanism of extracellular electrical stimulation, we developed down-staircase-shape stimulation which can achieve selective activation of targeted axons without generating anodal break excitation near the electrode. Systematic simulation revealed that the down-staircase stimulation is better than the up-staircase one in terms of distance-selectivity of axon recruitment. However, diameter-selectivity of both stimulations was not sufficient.

Original languageEnglish
Pages (from-to)896-903
Number of pages8
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume49
Issue number6
Publication statusPublished - 2011

Keywords

  • Myelinated axon
  • Selective nerve stimulation
  • Staircase-shape electrical stimulation

ASJC Scopus subject areas

  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Spatio-temporal dynamics of a myelinated nerve fiber model in response to staircase-shape extracellular electrical stimulation'. Together they form a unique fingerprint.

Cite this