Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo

Tomohiro Kurisaki, Aki Masuda, Noriko Osumi, Yo Ichi Nabeshima, Atsuko Fujisawa-Sehara

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)

Abstract

The cloning of the full-length cDNA encoding meltrin β (ADAM19), one of the metalloprotease-disintegrins expressed in mouse myogenic cells, revealed that the meltrin β gene encodes a membrane protein closely related to meltrin α (ADAM12) which participates in myotube formation in vitro. To delineate the functions of meltrin α and β, we examined the expression patterns of their transcripts during embryogenesis. The meltrin α gene is activated in condensed mesenchymal cells that give rise to skeletal muscle, bones and visceral organs. Meltrin β mRNA, in contrast, is markedly expressed in craniofacial and dorsal root ganglia and ventral horns of the spinal cord, where peripheral neuronal cell lineages differentiate. Heart, skeletal muscle, intestine and lung also express meltrin β mRNA transiently. Although the meltrin α and β transcripts exhibit distinct expression patterns during embryogenesis, both genes are mainly activated in mesenchymal cells that are derived from both mesoderm and ectoderm.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalMechanisms of Development
Volume73
Issue number2
DOIs
Publication statusPublished - 1998 May
Externally publishedYes

Keywords

  • ADAM
  • ADAM12
  • ADAM19
  • Bone
  • Disintegrin
  • Dorsal root ganglia
  • Lung
  • Meltrin α
  • Meltrin β
  • Metalloprotease
  • Motor neuron
  • Muscle
  • Myogenesis
  • Neu rogenesis
  • Osteogenesis
  • Sensory neuron

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo'. Together they form a unique fingerprint.

Cite this