TY - JOUR
T1 - Spatial coefficient of variation in pseudo-continuous arterial spin labeling cerebral blood flow images as a hemodynamic measure for cerebrovascular steno-occlusive disease
T2 - A comparative 15 O positron emission tomography study
AU - Ibaraki, Masanobu
AU - Nakamura, Kazuhiro
AU - Toyoshima, Hideto
AU - Takahashi, Kazuhiro
AU - Matsubara, Keisuke
AU - Umetsu, Atsushi
AU - Pfeuffer, Josef
AU - Kuribayashi, Hideto
AU - Kinoshita, Toshibumi
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by JSPS KAKENHI Grant Number 2315K09942.
Publisher Copyright:
© The Author(s) 2018.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Pseudo-continuous arterial spin labeling (pCASL) is a completely non-invasive method of cerebral perfusion measurement. However, cerebral blood flow (CBF) quantification is hampered by arterial transit artifacts characterized by bright vascular signals surrounded by decreased signals in tissue regions, which commonly appear in patients with reduced cerebral perfusion pressure. The spatial coefficient of variation (CoV) of pCASL CBF images has been proposed as an alternative region-of-interest (ROI)-based hemodynamic measure to predict prolonged arterial transit time (ATT). This retrospective study investigates the utility of spatial CoV by comparison with 15 O positron emission tomography (PET). For patients with cerebrovascular steno-occlusive disease (n = 17), spatial CoV was positively correlated with ATT independently measured by pulsed arterial spin labeling (r = 0.597, p < 0.001), confirming its role as an ATT-like hemodynamic measure. Comparisons with 15 O PET demonstrated that spatial CoV was positively correlated with vascular mean transit time (r = 0.587, p < 0.001) and negatively correlated with both resting CBF (r = −0.541, p = 0.001) and CBF response to hypercapnia (r = −0.373, p = 0.030). ROI-based spatial CoV calculated from single time-point pCASL can potentially detect subtle perfusion abnormalities in clinical settings.
AB - Pseudo-continuous arterial spin labeling (pCASL) is a completely non-invasive method of cerebral perfusion measurement. However, cerebral blood flow (CBF) quantification is hampered by arterial transit artifacts characterized by bright vascular signals surrounded by decreased signals in tissue regions, which commonly appear in patients with reduced cerebral perfusion pressure. The spatial coefficient of variation (CoV) of pCASL CBF images has been proposed as an alternative region-of-interest (ROI)-based hemodynamic measure to predict prolonged arterial transit time (ATT). This retrospective study investigates the utility of spatial CoV by comparison with 15 O positron emission tomography (PET). For patients with cerebrovascular steno-occlusive disease (n = 17), spatial CoV was positively correlated with ATT independently measured by pulsed arterial spin labeling (r = 0.597, p < 0.001), confirming its role as an ATT-like hemodynamic measure. Comparisons with 15 O PET demonstrated that spatial CoV was positively correlated with vascular mean transit time (r = 0.587, p < 0.001) and negatively correlated with both resting CBF (r = −0.541, p = 0.001) and CBF response to hypercapnia (r = −0.373, p = 0.030). ROI-based spatial CoV calculated from single time-point pCASL can potentially detect subtle perfusion abnormalities in clinical settings.
KW - Arterial transit artifact
KW - arterial transit time
KW - cerebral blood flow
KW - pseudo-continuous arterial spin labeling
KW - spatial coefficient of variation
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U2 - 10.1177/0271678X18781667
DO - 10.1177/0271678X18781667
M3 - Article
C2 - 29869933
AN - SCOPUS:85048077181
VL - 39
SP - 173
EP - 181
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 1
ER -