Spatial coefficient of variation in pseudo-continuous arterial spin labeling cerebral blood flow images as a hemodynamic measure for cerebrovascular steno-occlusive disease: A comparative 15 O positron emission tomography study

Masanobu Ibaraki, Kazuhiro Nakamura, Hideto Toyoshima, Kazuhiro Takahashi, Keisuke Matsubara, Atsushi Umetsu, Josef Pfeuffer, Hideto Kuribayashi, Toshibumi Kinoshita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pseudo-continuous arterial spin labeling (pCASL) is a completely non-invasive method of cerebral perfusion measurement. However, cerebral blood flow (CBF) quantification is hampered by arterial transit artifacts characterized by bright vascular signals surrounded by decreased signals in tissue regions, which commonly appear in patients with reduced cerebral perfusion pressure. The spatial coefficient of variation (CoV) of pCASL CBF images has been proposed as an alternative region-of-interest (ROI)-based hemodynamic measure to predict prolonged arterial transit time (ATT). This retrospective study investigates the utility of spatial CoV by comparison with 15 O positron emission tomography (PET). For patients with cerebrovascular steno-occlusive disease (n = 17), spatial CoV was positively correlated with ATT independently measured by pulsed arterial spin labeling (r = 0.597, p < 0.001), confirming its role as an ATT-like hemodynamic measure. Comparisons with 15 O PET demonstrated that spatial CoV was positively correlated with vascular mean transit time (r = 0.587, p < 0.001) and negatively correlated with both resting CBF (r = −0.541, p = 0.001) and CBF response to hypercapnia (r = −0.373, p = 0.030). ROI-based spatial CoV calculated from single time-point pCASL can potentially detect subtle perfusion abnormalities in clinical settings.

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume39
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1
Externally publishedYes

Keywords

  • Arterial transit artifact
  • arterial transit time
  • cerebral blood flow
  • pseudo-continuous arterial spin labeling
  • spatial coefficient of variation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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