Soy intake and vasomotor menopausal symptoms among midlife women: a pooled analysis of five studies from the InterLACE consortium

Yashvee Dunneram, Hsin Fang Chung, Janet E. Cade, Darren C. Greenwood, Annette J. Dobson, Ellen S. Mitchell, Nancy F. Woods, Eric J. Brunner, Toyoko Yoshizawa, Debra Anderson, Gita D. Mishra

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background/objectives: Phytoestrogen rich-foods such as soy may be associated with less frequent/severe vasomotor menopausal symptoms (VMS), although evidence is limited. We thus investigated the associations between the consumption of soy products and soy milk and the frequency/severity of VMS. Subjects/methods: We pooled data from 19,351 middle-aged women from five observational studies in Australia, UK, USA, and Japan that contribute to the International Collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE). Information on soy consumption, VMS and covariates were collected by self-report. We included 11,006 women who had complete data on soy consumption, VMS and covariates at baseline for the cross-sectional analysis. For the prospective analysis, 4522 women who were free of VMS at baseline and had complete data on VMS at follow-up were considered. Multinomial logistic regression and binary logistic regression models were used. Results: No statistically significant evidence of an association was found between soy products (relative risk ratio (RRR): 0.92, 95% CI: 0.76–1.11) or soy milk (RRR: 1.24, 95% CI: 0.93–1.65) and the likelihood of reporting frequent or severe VMS cross-sectionally. Prospective results indicated that frequent consumption of soy products (odds ratio (OR): 0.63, 95% CI: 0.45–0.89) but not soy milk (OR: 1.11, 95% CI: 0.85–1.45) was associated with lower likelihood of reporting subsequent VMS, after adjustment for socio-demographic and reproductive factors. Conclusions: These are the first ever findings from pooled observational data of association between consumption of soy products and VMS.

Original languageEnglish
Pages (from-to)1501-1511
Number of pages11
JournalEuropean Journal of Clinical Nutrition
Issue number11
Publication statusPublished - 2019 Nov 1

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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