Sonodynamically-induced in vitro cell damage enhanced by adriamycin

Shin Ichiro Umemura, Nagahiko Yumita, Yukihiro Okano, Masahiro Kaneuchi, Naoki Magario, Midori Ishizaki, Keiko Shimizu, Yasuko Sano, Koshiro Umemura, Ryuichiro Nishigaki

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalCancer Letters
Issue number2
Publication statusPublished - 1997 Dec 23
Externally publishedYes


  • Active oxygen
  • Adriamycin
  • Cell damage
  • Sonochemistry
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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