Sonodynamically-induced in vitro cell damage enhanced by adriamycin

Shin Ichiro Umemura; Nagahiko Yumita; Yukihiro Okano; Masahiro Kaneuchi; Naoki Magario; Midori Ishizaki; Keiko Shimizu; Yasuko Sano; Koshiro Umemura; Ryuichiro Nishigaki

doi:10.1016/S0304-3835(97)00354-6

Sonodynamically-induced in vitro cell damage enhanced by adriamycin

Shin Ichiro Umemura, Nagahiko Yumita, Yukihiro Okano, Masahiro Kaneuchi, Naoki Magario, Midori Ishizaki, Keiko Shimizu, Yasuko Sano, Koshiro Umemura, Ryuichiro Nishigaki

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.

Original language	English
Pages (from-to)	195-201
Number of pages	7
Journal	Cancer Letters
Volume	121
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(97)00354-6
Publication status	Published - 1997 Dec 23
Externally published	Yes

Keywords

Active oxygen
Adriamycin
Cell damage
Sonochemistry
Ultrasound

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(97)00354-6

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Sonodynamically-induced in vitro cell damage enhanced by adriamycin. / Umemura, Shin Ichiro; Yumita, Nagahiko; Okano, Yukihiro; Kaneuchi, Masahiro; Magario, Naoki; Ishizaki, Midori; Shimizu, Keiko; Sano, Yasuko; Umemura, Koshiro; Nishigaki, Ryuichiro.

In: Cancer Letters, Vol. 121, No. 2, 23.12.1997, p. 195-201.

Research output: Contribution to journal › Article › peer-review

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abstract = "Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.",

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AU - Umemura, Shin Ichiro

AU - Yumita, Nagahiko

AU - Okano, Yukihiro

AU - Kaneuchi, Masahiro

AU - Magario, Naoki

AU - Ishizaki, Midori

AU - Shimizu, Keiko

AU - Sano, Yasuko

AU - Umemura, Koshiro

AU - Nishigaki, Ryuichiro

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N2 - Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.

AB - Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.

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KW - Cell damage

KW - Sonochemistry

KW - Ultrasound

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JF - Cancer Letters

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Sonodynamically-induced in vitro cell damage enhanced by adriamycin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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