Abstract
Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.
Original language | English |
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Pages (from-to) | 195-201 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 121 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1997 Dec 23 |
Keywords
- Active oxygen
- Adriamycin
- Cell damage
- Sonochemistry
- Ultrasound
ASJC Scopus subject areas
- Oncology
- Cancer Research