Sonodynamically-induced in vitro cell damage enhanced by adriamycin

Shin Ichiro Umemura; Nagahiko Yumita; Yukihiro Okano; Masahiro Kaneuchi; Naoki Magario; Midori Ishizaki; Keiko Shimizu; Yasuko Sano; Koshiro Umemura; Ryuichiro Nishigaki

doi:10.1016/S0304-3835(97)00354-6

Sonodynamically-induced in vitro cell damage enhanced by adriamycin

Shin Ichiro Umemura, Nagahiko Yumita, Yukihiro Okano, Masahiro Kaneuchi, Naoki Magario, Midori Ishizaki, Keiko Shimizu, Yasuko Sano, Koshiro Umemura, Ryuichiro Nishigaki

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Sonodynamically-induced cell damage and active oxygen generation enhanced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-induced cell damage and nitroxide generation was demonstrated with 40-160 μM ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was suppressed by 10 mM histidine. These results are consistent with the hypothesis that ultrasonically-generated active oxygen plays a major role in the sonodynamically-induced cell damage enhanced by ADM.

Original language	English
Pages (from-to)	195-201
Number of pages	7
Journal	Cancer Letters
Volume	121
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(97)00354-6
Publication status	Published - 1997 Dec 23

Keywords

Active oxygen
Adriamycin
Cell damage
Sonochemistry
Ultrasound

ASJC Scopus subject areas

Oncology
Cancer Research

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Sonodynamically-induced in vitro cell damage enhanced by adriamycin. / Umemura, Shin Ichiro; Yumita, Nagahiko; Okano, Yukihiro; Kaneuchi, Masahiro; Magario, Naoki; Ishizaki, Midori; Shimizu, Keiko; Sano, Yasuko; Umemura, Koshiro; Nishigaki, Ryuichiro.

In: Cancer Letters, Vol. 121, No. 2, 23.12.1997, p. 195-201.

Research output: Contribution to journal › Article › peer-review

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