Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

Nagahiko Yumita, Shin ichiro Umemura, Masahiro Kaneuchi, Yukihiro Okano, Naoki Magario, Midori Ishizaki, Keiko Shimizu, Yasuko Sano, Koshiro Umemura, Ryuichiro Nishigaki

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 μM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalCancer Letters
Issue number1-2
Publication statusPublished - 1998 Mar 13


  • Anthracycline derivative
  • Cell damage
  • Sarcoma 180
  • Sonochemical mechanism
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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