Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

Nagahiko Yumita; Shin ichiro Umemura; Masahiro Kaneuchi; Yukihiro Okano; Naoki Magario; Midori Ishizaki; Keiko Shimizu; Yasuko Sano; Koshiro Umemura; Ryuichiro Nishigaki

doi:10.1016/S0304-3835(97)00515-6

Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

Nagahiko Yumita, Shin ichiro Umemura, Masahiro Kaneuchi, Yukihiro Okano, Naoki Magario, Midori Ishizaki, Keiko Shimizu, Yasuko Sano, Koshiro Umemura, Ryuichiro Nishigaki

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 μM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.

Original language	English
Pages (from-to)	209-214
Number of pages	6
Journal	Cancer Letters
Volume	125
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(97)00515-6
Publication status	Published - 1998 Mar 13

Keywords

Anthracycline derivative
Cell damage
Sarcoma 180
Sonochemical mechanism
Ultrasound

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(97)00515-6

Cite this

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abstract = "The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 μM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.",

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T1 - Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

AU - Yumita, Nagahiko

AU - Umemura, Shin ichiro

AU - Kaneuchi, Masahiro

AU - Okano, Yukihiro

AU - Magario, Naoki

AU - Ishizaki, Midori

AU - Shimizu, Keiko

AU - Sano, Yasuko

AU - Umemura, Koshiro

AU - Nishigaki, Ryuichiro

PY - 1998/3/13

Y1 - 1998/3/13

N2 - The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 μM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.

AB - The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 μM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.

KW - Anthracycline derivative

KW - Cell damage

KW - Sarcoma 180

KW - Sonochemical mechanism

KW - Ultrasound

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Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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