Sonodynamically induced cell damage with 4'-o-tetrahydropyranyladriamycin, THP

N. Yumita; M. Kaneuchi; Y. Okano; R. Nishigaki; K. Umemura; Shinichiro Umemura

Sonodynamically induced cell damage with 4'-o-tetrahydropyranyladriamycin, THP

N. Yumita, M. Kaneuchi, Y. Okano, R. Nishigaki, K. Umemura, Shinichiro Umemura

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background. 4'-O-tetrahydropyranyladriamycin (THP) is a novel anthracycline derivative with cardiotoxicity significantly lower than ADM. In this study, the ultrasonically induced induced in vitro cell damaging effect of THP was investigated. Materials and Methods. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and abscence of THP. The viability of the isolated cells was determined by staining of the cells with Trypan Blue dye. Results. The rate of inducing cell damage with ultrasound was doubled with 80 μM THP, while no cell damage was observed with THP alone. Conclusions. The enhancement of ultrasonically induced in vitro cell damage was demonstrated with THP. This enhancement was significantly inhibited by histidine, which mat suggest a sonochemical mechanism.

Original language	English
Pages (from-to)	281-284
Number of pages	4
Journal	Anticancer research
Volume	19
Issue number	1 A
Publication status	Published - 1999 Apr 20

Keywords

Anthracycline derivative
Sarcoma 180
Sonochemical mechanism
Sonodynamic therapy
Ultrasound

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Sonodynamically induced cell damage with 4'-o-tetrahydropyranyladriamycin, THP",

abstract = "Background. 4'-O-tetrahydropyranyladriamycin (THP) is a novel anthracycline derivative with cardiotoxicity significantly lower than ADM. In this study, the ultrasonically induced induced in vitro cell damaging effect of THP was investigated. Materials and Methods. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and abscence of THP. The viability of the isolated cells was determined by staining of the cells with Trypan Blue dye. Results. The rate of inducing cell damage with ultrasound was doubled with 80 μM THP, while no cell damage was observed with THP alone. Conclusions. The enhancement of ultrasonically induced in vitro cell damage was demonstrated with THP. This enhancement was significantly inhibited by histidine, which mat suggest a sonochemical mechanism.",

keywords = "Anthracycline derivative, Sarcoma 180, Sonochemical mechanism, Sonodynamic therapy, Ultrasound",

author = "N. Yumita and M. Kaneuchi and Y. Okano and R. Nishigaki and K. Umemura and Shinichiro Umemura",

year = "1999",

month = apr,

day = "20",

language = "English",

volume = "19",

pages = "281--284",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "1 A",

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TY - JOUR

T1 - Sonodynamically induced cell damage with 4'-o-tetrahydropyranyladriamycin, THP

AU - Yumita, N.

AU - Kaneuchi, M.

AU - Okano, Y.

AU - Nishigaki, R.

AU - Umemura, K.

AU - Umemura, Shinichiro

PY - 1999/4/20

Y1 - 1999/4/20

N2 - Background. 4'-O-tetrahydropyranyladriamycin (THP) is a novel anthracycline derivative with cardiotoxicity significantly lower than ADM. In this study, the ultrasonically induced induced in vitro cell damaging effect of THP was investigated. Materials and Methods. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and abscence of THP. The viability of the isolated cells was determined by staining of the cells with Trypan Blue dye. Results. The rate of inducing cell damage with ultrasound was doubled with 80 μM THP, while no cell damage was observed with THP alone. Conclusions. The enhancement of ultrasonically induced in vitro cell damage was demonstrated with THP. This enhancement was significantly inhibited by histidine, which mat suggest a sonochemical mechanism.

AB - Background. 4'-O-tetrahydropyranyladriamycin (THP) is a novel anthracycline derivative with cardiotoxicity significantly lower than ADM. In this study, the ultrasonically induced induced in vitro cell damaging effect of THP was investigated. Materials and Methods. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and abscence of THP. The viability of the isolated cells was determined by staining of the cells with Trypan Blue dye. Results. The rate of inducing cell damage with ultrasound was doubled with 80 μM THP, while no cell damage was observed with THP alone. Conclusions. The enhancement of ultrasonically induced in vitro cell damage was demonstrated with THP. This enhancement was significantly inhibited by histidine, which mat suggest a sonochemical mechanism.

KW - Anthracycline derivative

KW - Sarcoma 180

KW - Sonochemical mechanism

KW - Sonodynamic therapy

KW - Ultrasound

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M3 - Article

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VL - 19

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JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 1 A

ER -

Sonodynamically induced cell damage with 4'-o-tetrahydropyranyladriamycin, THP

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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