Sonodynamically induced cell damage with 4'-o-tetrahydropyranyladriamycin, THP

N. Yumita, M. Kaneuchi, Y. Okano, R. Nishigaki, K. Umemura, Shinichiro Umemura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background. 4'-O-tetrahydropyranyladriamycin (THP) is a novel anthracycline derivative with cardiotoxicity significantly lower than ADM. In this study, the ultrasonically induced induced in vitro cell damaging effect of THP was investigated. Materials and Methods. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and abscence of THP. The viability of the isolated cells was determined by staining of the cells with Trypan Blue dye. Results. The rate of inducing cell damage with ultrasound was doubled with 80 μM THP, while no cell damage was observed with THP alone. Conclusions. The enhancement of ultrasonically induced in vitro cell damage was demonstrated with THP. This enhancement was significantly inhibited by histidine, which mat suggest a sonochemical mechanism.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalAnticancer research
Issue number1 A
Publication statusPublished - 1999 Apr 20


  • Anthracycline derivative
  • Sarcoma 180
  • Sonochemical mechanism
  • Sonodynamic therapy
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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