Sonodynamically induced antitumor effect of pheophorbide a

Koshiro Umemura, Nagahiko Yumita, Ryuichiro Nishigaki, Shin Ichiro Umemura

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


The sonodynamically induced antitumor effect of pheophorbide a (Ph-a) was investigated. Both in vitro and in vivo effects on sarcoma 180 were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced cell damage in air-saturated suspension was enhanced by twice with 80μM Ph-a. This enhancement was significantly inhibited by histidine, which may suggest it was mediated by ultrasonically induced oxidation. For mice, 5 mg/kg Ph-a was administered before the insonation, and ultrasound stopped the tumor growth at an intensity with which ultrasound alone showed only a slight anti-tumor effect.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalCancer Letters
Issue number1-2
Publication statusPublished - 1996 Apr 19


  • Antitumor effect
  • Pheophorbide
  • Sarcoma 180
  • Sonodynamic therapy
  • Ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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